| Identification | Back Directory | [Name]
PF 03382792 | [CAS]
1400811-63-3 | [Synonyms]
PF-3382792
PF 03382792
6-fluoro-N-[[1-[(4-hydroxyoxan-4-yl)methyl]piperidin-4-yl]methyl]-3,3-dimethyl-2-oxoindole-1-carboxamide
6-fluoro-N-((1-((4-hydroxytetrahydro-2H-pyran-4-yl)methyl)piperidin-4-yl)methyl)-3,3-dimethyl-2-oxoindoline-1-carboxamide
1H-Indole-1-carboxamide, 6-fluoro-2,3-dihydro-3,3-dimethyl-2-oxo-N-[[1-[(tetrahydro-4-hydroxy-2H-pyran-4-yl)methyl]-4-piperidinyl]methyl]- | [Molecular Formula]
C23H32FN3O4 | [MDL Number]
MFCD25976982 | [MOL File]
1400811-63-3.mol | [Molecular Weight]
433.52 |
| Hazard Information | Back Directory | [Uses]
PF-03382792 is a potent 5-HT4 partial agonist with a Ki of 2.7 nM and an EC50 of 0.9 nM for 5-HT4d. PF-03382792 can penetrate the brain. PF-03382792 produces moderate increases in cortical Ach in the rat prefrontal cortex[1]. | [IC 50]
5-HT4d Receptor: 2.7 nM (Ki); 5-HT4d Receptor: 0.9 nM (EC50) | [References]
[1] Michael A Brodney, et al.Identification of multiple 5-HT? partial agonist clinical candidates for the treatment of Alzheimer's disease. J Med Chem. 2012 Nov 8;55(21):9240-54. DOI:10.1021/jm300953p |
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