| Identification | Back Directory | [Name]
(+/-)-EPIBATIDINE | [CAS]
140111-52-0 | [Synonyms]
(+)-Epibatidine
(+/-)-EPIBATIDINE
(+/-)-EpibatidineHCl
(+/-)-EPIBATIDINE USP/EP/BP
(+-)-EPIBATIDINE DIHYDROCHLORIDE SYNTHET IC >99%
2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
(±)-exo-2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane
7-Azabicyclo(2.2.1)heptane, 2-(6-chloro-3-pyridinyl)-, exo-
(2R,4S)-2-(6-chloropyridin-3-yl)-7-azabicyclo[2.2.1]heptane
7-Azabicyclo(2.2.1)heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)- | [Molecular Formula]
C11H13ClN2 | [MDL Number]
MFCD00923801 | [MOL File]
140111-52-0.mol | [Molecular Weight]
208.69 |
| Chemical Properties | Back Directory | [Boiling point ]
336.7±32.0 °C(Predicted) | [density ]
1.223±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [form ]
White solid. | [pka]
10.07±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
(+)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors. | [Synthesis Reference(s)]
[1] Simon C. Clayton,Andrew C. Regan. A total synthesis of (±)-epibatidine. Tetrahedron Letters. Volume 34, Issue 46, 12 November 1993, Pages 7493-7496. | [Biological Activity]
Very potent nicotinic agonist (K i values are 0.02 and 233 nM for α 4 β 2 and α 7 nicotinic receptors respectively). Analgesic. | [Synthesis]
Andrew C. Regan and colleagues reported a total synthesis of the potent non-opiate analgesic alkaloid epibatidine is described, in which the key step is a reductive palladium-catalysed Heck-type coupling.[1] (±)-Epibatidine has being synthesised, employing a reductive palladium-catalysed coupling as the key reaction.
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ETA SCIENTIFIC Co.,Ltd
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