| Identification | Back Directory | [Name]
N-hydroxy-2-(((2-(6-methoxypyridin-3-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)(methyl)amino)pyrimidine-5-carboxamidemethanesulfonate | [CAS]
1401998-36-4 | [Synonyms]
EOS-60340
CUDC-907 mesylate | [Molecular Formula]
C24H28N8O7S2 | [MOL File]
1401998-36-4.mol | [Molecular Weight]
604.66 |
| Hazard Information | Back Directory | [Uses]
Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC50 of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively. | [References]
[1] Qian C, et al. Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling. Clin Cancer Res. 2012 Aug 1;18(15):4104-13. DOI:10.1158/1078-0432.CCR-12-0055 |
|
|