| Identification | Back Directory | [Name]
Randialic acid B | [CAS]
14021-14-8 | [Synonyms]
Randialic acid B
Ursa-12,18-dien-28-oic acid, 3-hydroxy-, (3β)- | [Molecular Formula]
C30H46O3 | [MDL Number]
MFCD34470925 | [MOL File]
14021-14-8.mol | [Molecular Weight]
454.7 |
| Chemical Properties | Back Directory | [Boiling point ]
572.6±50.0 °C(Predicted) | [density ]
1.11±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [form ]
Solid | [pka]
4.59±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo[1]. | [in vivo]
Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss[1]. | Animal Model: | BALB/c white female mice (20 g weight; 7-week-old) treated with Imiquimod[1] | | Dosage: | 10 mg/kg
| | Administration: | i.v.; every other day; for 5 days | | Result: | Significantly reduced Imiquimod-induced psoriasis-like symptoms. |
| [References]
[1] Michal Korinek, et al. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem Pharmacol. 2021 Aug;190:114596. DOI:10.1016/j.bcp.2021.114596
[2] Shan-Shan Li, et al. Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H 2 O 2-induced myocardial cell injury. Chin J Nat Med. 2017 Feb;15(2):115-120. DOI:10.1016/S1875-5364(17)30027-4 |
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