| Identification | Back Directory | [Name]
PF-06273340 | [CAS]
1402438-74-7 | [Synonyms]
PF-06273340
PF-06273340 >=98% (HPLC)
BPIWZDNVMQQBQX-UHFFFAOYSA-N
N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide
N-[5-[2-AMINO-7-(1-HYDROXY-2-METHYLPROPAN-2-YL)PYRROLO[2,3-D]PYRIMIDINE-5-CARBONYL]PYRIDIN-3-YL]-2-(5-CHLOROPYRIDIN-2-YL)ACETAMIDE
2-Pyridineacetamide, N-[5-[[2-amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-
N-(5-(2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-3-yl)-2-(5-chloropyridin-2-yl)acetamide | [Molecular Formula]
C23H22ClN7O3 | [MDL Number]
MFCD28902308 | [MOL File]
1402438-74-7.mol | [Molecular Weight]
479.92 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
12.40±0.70(Predicted) | [color ]
Light yellow to yellow | [InChIKey]
BPIWZDNVMQQBQX-UHFFFAOYSA-N | [SMILES]
CC(CO)(C)N1C2=NC(N)=NC=C2C(C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=C1 |
| Hazard Information | Back Directory | [Uses]
PF-06273340 is a potent, selective, orally bioavailable and peripherally restricted pan Trk inhibitor[1]. | [Biological Activity]
PF-06273340 is a brain penetrantorally available and potent tropomyosin-related kinase (Trk) inhibitor. PF-06273340 is under development as a remedy acute and chronic pain. | [IC 50]
TRK | [storage]
Store at RT | [References]
[1] Skerratt SE, et al. The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain. DOI:10.1021/acs.jmedchem.6b00850 |
|
| Company Name: |
ChemCell Biomedicine Co.,Ltd.
|
| Tel: |
020-13556033878 2965585218 13556033878 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
|