| Identification | Back Directory | [Name]
L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro- | [CAS]
1402453-15-9 | [Synonyms]
ATIC-IN-1
L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro- | [Molecular Formula]
C21H33N7O5 | [MOL File]
1402453-15-9.mol | [Molecular Weight]
463.53 |
| Chemical Properties | Back Directory | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble | [form ]
Solid | [pka]
13.23±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
ATIC''Reversible: yes | [References]
[1] Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13(11):1628-34. DOI:10.1002/cbic.201200279 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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