| Identification | Back Directory | [Name]
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate | [CAS]
1402931-66-1 | [Synonyms]
Methyl (1R,2R,3S,3aR,8bS)-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-6-(methylamino)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylate | [Molecular Formula]
C28H29NO7 | [MOL File]
1402931-66-1.mol | [Molecular Weight]
491.53 |
| Chemical Properties | Back Directory | [Boiling point ]
640.7±55.0 °C(Predicted) | [density ]
1.362±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
11.79±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
eIF4A3-IN-15 (compound 52) is a silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC50s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis[1]. | [References]
[1] Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. DOI:10.1021/jm3011542 |
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