| Identification | Back Directory | [Name]
3H-Pyrazol-3-one, 2-cycloheptyl-2,4-dihydro-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethyl- | [CAS]
1403598-56-0 | [Synonyms]
3H-Pyrazol-3-one, 2-cycloheptyl-2,4-dihydro-5-[4-methoxy-3-[4-[4-(2H-tetrazol-5-yl)phenoxy]butoxy]phenyl]-4,4-dimethyl- | [Molecular Formula]
C30H38N6O4 | [MOL File]
1403598-56-0.mol | [Molecular Weight]
546.66 |
| Chemical Properties | Back Directory | [Boiling point ]
714.0±70.0 °C(Predicted) | [density ]
1.28±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
4.48±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
DNMT3A-IN-1 (compound 1) is an effective and selective DNMT3A inhibitor. DNMT3A-IN-1 exhibits inhibitory activity against DNMT3A, with KI values ranging from 9.16 to 18.85 μM (AdoMet) and 11.37 to 23.34 μM (poly dI-dC). DNMT3A-IN-1 can induce apoptosis in acute myeloid leukemia (AML) cell lines (Apoptosis)[1][2]. | [Biological Activity]
DNMT3A-IN-1 is a potent and selective DNMT3A inhibitor. DNMT3A-IN-1 shows inhibitor activities against DNMT3A with kI values range from 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC) [1]. | [IC 50]
DNMT3A | [storage]
Store at -20°C | [References]
[1]. Huang S, et al. A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A. Bioorg Med Chem Lett. 2021; 40:127908. |
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