| Identification | Back Directory | [Name]
Nexturastat A | [CAS]
1403783-31-2 | [Synonyms]
Nexturastat A
Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
Nexturastat A Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
Nexturastat A 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE | [Molecular Formula]
C19 H23 N3 O3 | [MDL Number]
MFCD28099804 | [MOL File]
1403783-31-2.mol | [Molecular Weight]
341.4 |
| Chemical Properties | Back Directory | [density ]
1.228±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH | [form ]
solid | [pka]
8.95±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C19H23N3O3/c1-2-3-13-22(19(24)20-17-7-5-4-6-8-17)14-15-9-11-16(12-10-15)18(23)21-25/h4-12,25H,2-3,13-14H2,1H3,(H,20,24)(H,21,23) | [InChIKey]
JZWXMCPARMXZQV-UHFFFAOYSA-N | [SMILES]
C(NO)(=O)C1=CC=C(CN(CCCC)C(NC2=CC=CC=C2)=O)C=C1 |
| Hazard Information | Back Directory | [Uses]
Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells. | [Biological Activity]
nexturastat a is a selective inhibitor of histone deacetylase 6 (hdac6) with ic50 value of 5.2 nm [1].nexturastat a is a hdac inhibitor. it was developed by structural modification of aryl urea hdacis. the inhibitory activity of nexturastat a is most potent against hdac6 with ic50 value of 5.2 nm. besides that, nexturastat a also shows inhibition of other hdacs with ic50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μm for hdac1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. nexturastat a has been shown to suppress cell proliferation and promote apoptosis in b16 murine melanoma cells [1, 2]. | [in vivo]
Nexturastat A (NexA) (every two days, 20 days) inhibits tumor growth in murine xenograft models of MM[2]. | [target]
HDAC6 | [IC 50]
HDAC6: 5.02 nM (IC50); HDAC8: 0.954 μM (IC50); HDAC1: 3.02 μM (IC50); HDAC7: 4.46 μM (IC50); HDAC11: 5.14 μM (IC50); HDAC3: 6.68 μM (IC50); HDAC9: 6.72 μM (IC50); HDAC2: 6.92 μM (IC50); HDAC10: 7.57 μM (IC50); HDAC4: 9.39 μM (IC50); HDAC5: 11.7 μM (IC50) | [References]
[1] kalin j h, bergman j a. development and therapeutic implications of selective histone deacetylase 6 inhibitors. journal of medicinal chemistry, 2013, 56(16): 6297-6313.
[2] zhang l, han y, jiang q, et al. trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. medicinal research reviews, 2014. |
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| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|