| Identification | Back Directory | [Name]
CC-90001 | [CAS]
1403859-14-2 | [Synonyms]
CC90001
CC-90001
CC90001 free base
CC90001,kinase,IPF,JNK,c-Jun,idiopathic,JNK1,Inhibitor,N-terminal,inhibit,CC-90001,CC 90001,fibrosis,pulmonary | [Molecular Formula]
C16H27N5O2 | [MDL Number]
MFCD33029314 | [MOL File]
1403859-14-2.mol | [Molecular Weight]
321.42 |
| Chemical Properties | Back Directory | [Boiling point ]
549.5±60.0 °C(Predicted) | [density ]
1.224±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 250 mg/mL (777.80 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.17±0.50(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis[1][2]. | [in vivo]
CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model[1].
CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis[1]. | [IC 50]
JNK1; JNK2 | [storage]
Store at -20°C | [References]
[1] Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.
[2] Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57. DOI:10.1016/j.rmed.2017.07.062 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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