| Identification | Back Directory | [Name]
ON 146040 | [CAS]
1404231-34-0 | [Synonyms]
ON 146040
(7Z)-2-[4-(4-methylpiperazin-1-yl)anilino]-7-[(4-nitrophenyl)methylidene]-5H-pyrimido[4,5-b][1,4]thiazin-6-one
5H-Pyrimido[4,5-b][1,4]thiazin-6(7H)-one, 2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-7-[(4-nitrophenyl)methylene]- | [Molecular Formula]
C24H23N7O3S | [MDL Number]
MFCD28167819 | [MOL File]
1404231-34-0.mol | [Molecular Weight]
489.55 |
| Hazard Information | Back Directory | [Uses]
ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM). | [IC 50]
PI3Kα: 14 nM (IC50); PI3Kδ: 20 nM (IC50); PI3Kγ: 1 μM (IC50); PI3Kβ: 3 μM (IC50) | [References]
[1] Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL. |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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