| Identification | Back Directory | [Name]
5-Benzofurancarboxylic acid, 3-[2-(3-chlorophenyl)ethynyl]-2-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]-6-hydroxy- | [CAS]
1404436-51-6 | [Synonyms]
LYP-IN-1
5-Benzofurancarboxylic acid, 3-[2-(3-chlorophenyl)ethynyl]-2-[4-[2-(cyclopropylamino)-2-oxoethoxy]phenyl]-6-hydroxy- | [Molecular Formula]
C28H20ClNO6 | [MOL File]
1404436-51-6.mol | [Molecular Weight]
501.91 |
| Chemical Properties | Back Directory | [Boiling point ]
703.7±60.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
2?+-.0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
LYP-IN-1 is a potent, selective and specific LYP inhibitor. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 and SHP2. It can be used in study of autoimmune disorders. | [Uses]
LYP-IN-1 is a potent, selective and specific LYP inhibitor with a Ki and an IC50 of 110 nM and 0.259 μM, respectively. LYP-IN-1 also has selectivity for a large panel of PTPs, such as SHP1 (IC50=5 μM) and SHP2 (IC50=2.5 μM). LYP-IN-1 exhibits highly efficacious cellular activity in T- and mast cells. LYP-IN-1 can be used for the study of autoimmune disorders[1]. LYP-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] A Potent and Selective Small-Molecule Inhibitor for the Lymphoid-Specific Tyrosine Phosphatase (LYP), a Target Associated With Autoimmune Diseases DOI:10.1021/jm400248c |
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