| Identification | Back Directory | [Name]
PF 06465469
Discontinued See A191400 | [CAS]
1407966-77-1 | [Synonyms]
PF 06465469
PF 06465469
Discontinued See A191400
(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide
(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide
3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide
Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]- | [Molecular Formula]
C32H35N5O2 | [MDL Number]
MFCD23381175 | [MOL File]
1407966-77-1.mol | [Molecular Weight]
521.653 |
| Chemical Properties | Back Directory | [Melting point ]
209-212°C | [Boiling point ]
730.2±60.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL, clear | [form ]
powder | [pka]
12.83±0.70(Predicted) | [color ]
white to beige | [InChIKey]
CGJVMKJGKFEHTL-HSZRJFAPSA-N | [SMILES]
N1(C[C@@H](CCC1)[n]2nc(c5c2ncnc5N)c3cc(ccc3)C(=O)Nc4cc(c(cc4)C(C)C)C)C(=O)C=C |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk).
Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc. | [Uses]
PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay. | [Biological Activity]
PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in immune cells, and is strongly upregulated following activation of T-cells. PF-06465469 inhibits Itk enzymatic activity with an IC50 of 2 nM. The compound blocks anti-CD3 induced phosphorylation of PLCg in Jurk at cells (IC50 = 31 nM) and IL-2 production in anti-CD3 stimulated human whole blood (IC50 = 48 nM). | [storage]
Store at +4°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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