| Identification | Back Directory | [Name]
NSC5844 | [CAS]
140926-75-6 | [Synonyms]
RE640
RE-640
RE 640
NSC5844
NSC5844 (RE640)
NSC 5844; NSC-5844; RE 640; RE-640; RE640
N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
1,2-Ethanediamine, N1,N2-bis(7-chloro-4-quinolinyl)- | [Molecular Formula]
C20H16Cl2N4 | [MDL Number]
MFCD29924743 | [MOL File]
140926-75-6.mol | [Molecular Weight]
383.27 |
| Chemical Properties | Back Directory | [Boiling point ]
632.6±55.0 °C(Predicted) | [density ]
1.431±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 0.33 mg/ml; DMSO: 0.25 mg/ml; Ethanol: slightly soluble | [form ]
A crystalline solid | [pka]
6.61±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 μM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 μM. | [Uses]
N1,N2-Bis(7-chloroquinolin-4-yl)ethane-1,2-diamine and other bisquinoline derivatives have potentials against chloroquine-resistant malaria. A useful intermediate for the preparation of other antimalarial bisaminoquinlines. | [IC 50]
Plasmodium | [References]
[1] JONATHAN L. VENNERSTROM. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria[J]. Journal of Medicinal Chemistry, 1992, 35 11: 2129-2134. DOI: 10.1021/jm00089a025
[2] HAIWEN ZHANG . Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives[J]. Biomedicine & Pharmacotherapy, 2008, 62 2: Pages 65-69. DOI: 10.1016/j.biopha.2007.04.007
[3] JAMES C BURNETT . Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity[J]. Biochemical and biophysical research communications, 2003, 310 1: Pages 84-93. DOI: 10.1016/j.bbrc.2003.08.112 |
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| Company Name: |
Grader reagent
|
| Tel: |
18221735425 |
| Website: |
www.shxinping.net |
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