| Identification | Back Directory | [Name]
Quinacrine analog 34 | [CAS]
1411646-44-0 | [Synonyms]
Quinacrine analog 34
9-Acridinamine, 6-chloro-1,2,3,4-tetrahydro-N-[2-(4-methyl-1-piperazinyl)ethyl]- | [Molecular Formula]
C20H27ClN4 | [MOL File]
1411646-44-0.mol | [Molecular Weight]
358.91 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Quinacrine analog 34 is an inhibitor of autophagy with a minimum effective concentration (MEC) of 0.5 μM in U2OS cells. It induces lysosomal deacidification and accumulation of LC3-II in the same cells when used at concentrations of 0.5 or 3 μM. | [Uses]
Autophagy-IN-4 (Compound 34) is an autophagy inhibitor, with an EC50 of 0.5 μM and a LD50 of 27 μM for U2OS cells[1]. | [References]
[1] Wang et al. Synthesis of improved lysomotropic autophagy inhibitors. J Med Chem. 2015 Apr 9;58(7):3025-35. DOI:10.1021/jm501586m |
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