| Identification | Back Directory | [Name]
SS28 | [CAS]
141172-08-9 | [Synonyms]
SS28
Benzene, 1,2,3-trimethoxy-5-[(1Z)-2-(4-methylphenyl)ethenyl]- | [Molecular Formula]
C18H20O3 | [MDL Number]
MFCD00925303 | [MOL File]
141172-08-9.mol | [Molecular Weight]
284.35 |
| Chemical Properties | Back Directory | [Boiling point ]
414.3±40.0 °C(Predicted) | [density ]
1.089±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO |
| Hazard Information | Back Directory | [Uses]
SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1]. | [in vivo]
SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1]. | Animal Model: | BALB/c mice using EAC cells[1]. | | Dosage: | 15 mg/kg. | | Administration: | Orally on every alternate day for 9 doses. | | Result: | There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice. |
| [References]
[1] Thomas E, et al. A Novel Resveratrol Based Tubulin Inhibitor Induces Mitotic Arrest and Activates Apoptosis in Cancer Cells. Sci Rep. 2016 Oct 17;6:34653. DOI:10.1038/srep34653 |
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cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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