| Identification | Back Directory | [Name]
H-GLY-PRO-GLY-NH2 HCL | [CAS]
141497-12-3 | [Synonyms]
GPG-NH2
H-Gly-Pro-Gly-NH2
H-GLY-PRO-GLY-NH2 HCL
Glycyl-L-prolylglycinamide
Glycinamide, glycyl-L-prolyl-
H-Gly-Pro-Gly-NH2 hydrochloride | [Molecular Formula]
C9H16N4O3 | [MDL Number]
MFCD30294771 | [MOL File]
141497-12-3.mol | [Molecular Weight]
228.25 |
| Chemical Properties | Back Directory | [Boiling point ]
618.0±55.0 °C(Predicted) | [density ]
1.326±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C
| [pka]
14.27±0.20(Predicted) | [Sequence]
H-Gly-Pro-Gly-NH2 · HCl |
| Hazard Information | Back Directory | [Uses]
H-Gly-Pro-Gly-NH2 is a tripeptide that inhibits HIV-1 replication. H-Gly-Pro-Gly-NH2 inhibits the activity of HIV-1 IIIB and HIV-2 ROD with EC50 values of 35 μM and 30 μM, respectively. H-Gly Pro Gly NH2 inhibits HIV-1 replication in vitro by interfering with capsid formation. H-Gly Pro Gly NH2 has antiviral activity and can be used for virus research[1][2][3]. | [IC 50]
HIV (IIIB): 35 μM (EC50); HIV-2 (ROD): 30 μM (EC50) | [References]
[1] H?glund S, et al. Tripeptide interference with human immunodeficiency virus type 1 morphogenesis. Antimicrob Agents Chemother. 2002 Nov;46(11):3597-605. DOI:10.1128/AAC.46.11.3597-3605.2002
[2] Andersson E, et al. No cross-resistance or selection of HIV-1 resistant mutants in vitro to the antiretroviral tripeptide glycyl-prolyl-glycine-amide[J]. Antiviral research, 2004, 61(2): 119-124.
[3] Balzarini J, et al. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Int J Biochem Cell Biol. 2004 Sep;36(9):1848-59. DOI:10.1016/j.biocel.2004.02.017 |
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