| Identification | Back Directory | [Name]
Benzamide, N-[3-[2-(cyclopropylamino)-6-quinazolinyl]-4-methylphenyl]-3-(trifluoromethyl)- | [CAS]
1415050-57-5 | [Synonyms]
Benzamide, N-[3-[2-(cyclopropylamino)-6-quinazolinyl]-4-methylphenyl]-3-(trifluoromethyl)- | [Molecular Formula]
C26H21F3N4O | [MOL File]
1415050-57-5.mol | [Molecular Weight]
462.47 |
| Hazard Information | Back Directory | [Description]
GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease. It acts by targeting ATP-binding pocket of IRE1α. | [Uses]
ERK2-IN-3 (compound 2) is a inhibitor of ERK2, and inhibits Erk2WT and Erk2DS1 activation loop phosphorylation, with IC50 of 5 μM and 42 nM, respectively[1]. | [References]
[1] Hari SB, et al. Conformation-selective ATP-competitive inhibitors control regulatory interactions and noncatalytic functions of mitogen-activated protein kinases. Chem Biol. 2014;21(5):628-635. DOI:10.1016/j.chembiol.2014.02.016 |
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