| Identification | Back Directory | [Name]
Benzamide, N-[3-[2-[[4-[2-(acetylamino)ethoxy]phenyl]amino]-6-quinazolinyl]-4-methylphenyl]-3-(trifluoromethyl)- | [CAS]
1415050-59-7 | [Synonyms]
GP29
GP-29
GP 29
Benzamide, N-[3-[2-[[4-[2-(acetylamino)ethoxy]phenyl]amino]-6-quinazolinyl]-4-methylphenyl]-3-(trifluoromethyl)- | [Molecular Formula]
C33H28F3N5O3 | [MOL File]
1415050-59-7.mol | [Molecular Weight]
599.6 |
| Hazard Information | Back Directory | [Description]
GP29 is a Type II kinase inhibitor of the IRE1α endoribonuclease. It acts by targeting the ATP-binding pocket of IRE1α. | [Uses]
IRE1α kinase-IN-10 (GP29) is an IRE1α kinase inhibitor. IRE1α kinase-IN-10 can be used for the research of endoplasmic reticulum stress-related diseases[1]. | [References]
[1] Wang L, et al. Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec;8(12):982-9. DOI:10.1038/nchembio.1094 |
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