| Identification | Back Directory | [Name]
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- | [CAS]
1415321-64-0 | [Synonyms]
Propanoic acid, 2-[2-chloro-5-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]phenoxy]-, (2S)- | [Molecular Formula]
C33H37ClN2O4 | [MOL File]
1415321-64-0.mol | [Molecular Weight]
561.11 |
| Chemical Properties | Back Directory | [Boiling point ]
773.7±60.0 °C(Predicted) | [density ]
1.19±0.1 g/cm3(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml | [form ]
Solid | [pka]
3.11±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
SR10221 is a PPARγ inverse-agonist. SR10221 represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. | [Uses]
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines[1]. | [References]
[1] Sean Irwin, et al. Biochemical and structural basis for the pharmacological inhibition of nuclear hormone receptor PPARγ by inverse agonists. J Biol Chem. 2022 Nov;298(11):102539. DOI:10.1016/j.jbc.2022.102539 |
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| Company Name: |
Biorbyt Ltd.
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+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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