| Identification | Back Directory | [Name]
1-(5-Isoquinolinesulfonyl)piperazine Hydrochloride | [CAS]
141543-63-7 | [Synonyms]
Fasudil Impurity 22 HCl
5-(piperazin-1-ylsulfonyl)isoquinoline hydrochloride | [Molecular Formula]
C13H16ClN3O2S | [MOL File]
141543-63-7.mol | [Molecular Weight]
313.8 |
| Chemical Properties | Back Directory | [Melting point ]
252-254°C | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water | [form ]
Solid | [color ]
Off-White to Light Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. | [Uses]
Exhibited potent inhibition toward protein kinase C and cyclic nucleotide dependent protein kinases. | [IC 50]
PKG: 4 μM (IC50); PKA: 8 μM (IC50); PKC: 12 μM (IC50); MLCK: 240 μM (IC50); ROCK | [References]
[1] Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12. PMID:2955213
[2] Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557. DOI:10.1371/journal.pone.0017557 |
|
| Company Name: |
Abcam Limited
|
| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
|