| Identification | Back Directory | [Name]
PtdIns-(3,4,5)-P3-biotinamide (sodium salt) | [CAS]
1415684-80-8 | [Synonyms]
IIJJVXPPNNJTJF-YNHNOJPWSA-J
PtdIns-(3,4,5)-P3-biotinamide (sodium salt) | [Molecular Formula]
C35H66N3NaO24P4S | [MDL Number]
MFCD28899351 | [MOL File]
1415684-80-8.mol | [Molecular Weight]
1091.85 |
| Hazard Information | Back Directory | [Description]
The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.1,2,3 PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins. | [Uses]
PtdIns-(3,4,5)-P3-biotin sodium is a Biotin-labeled PtdIns-(3,4,5)-P3 (PI(3,4,5)P3). PI(3,4,5)P3 is a substrate of nuclear phosphatidylinositol 5-phosphatase (PIP5Pase). PI(3,4,5)P3 binds to the N-terminus of RAP1 (repressor activator protein 1) and controls its DNA binding activity[1]. | [storage]
Store at -20°C | [References]
1. Majerus, P.W. Inositol phosphate biochemistry Annu. Rev. Biochem. 61,225-250(1992).
2. Exton, J.H. Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins Annu. Rev. Pharmacol. Toxicol. 36,481-509(1996).
3. Rückle, T., Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an 'aspirin of the 21st century'? Nat. Rev. Drug Discov. 5(11),903-918(2006). |
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