| Identification | Back Directory | [Name]
1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- | [CAS]
1416313-72-8 | [Synonyms]
Dynole 2-24
1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]- | [Molecular Formula]
C24H41N3 | [MOL File]
1416313-72-8.mol | [Molecular Weight]
371.6 |
| Chemical Properties | Back Directory | [Boiling point ]
495.0±30.0 °C(Predicted) | [density ]
0.96±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Oil | [pka]
10.27±0.19(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Dynole 2-24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2-24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2-24 also shows 4.4-fold selectivity for dynamin I. Dynole 2-24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis | [Uses]
Dynole 2?24 is an indole-based dynamin GTPase inhibitor (IC50=0.56 μM for dynamin I). Dynole 2?24 is nontoxic and shows increased potency against dynamin I and II in vitro and in cells (IC??(CME)=1.9 μM). Dynole 2?24 also shows 4.4-fold selectivity for dynamin I. Dynole 2?24 is active in-cell inhibitor of clathrin-mediated endocytosis[1]. CME: Clathrin mediated endocytosis | [storage]
Store at -20°C | [References]
[1] Gordon CP, Venn-Brown B, Robertson MJ, et al. Development of second-generation indole-based dynamin GTPase inhibitors. J Med Chem. 2013;56(1):46-59. DOI:10.1021/jm300844m |
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| Company Name: |
Abcam Limited
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| Tel: |
021-2070050 400921018 |
| Website: |
www.abcam.cn |
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