| Identification | Back Directory | [Name]
BOC-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2 | [CAS]
141663-86-7 | [Synonyms]
GR 87389
BOC-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2
L-Norleucinamide,N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl-
L-Norleucinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-L-alanyl-D-tryptophyl-L-phenylalanyl-D-prolyl-L-prolyl- (9CI) | [Molecular Formula]
C47H65N9O9 | [MDL Number]
MFCD00214617 | [MOL File]
141663-86-7.mol | [Molecular Weight]
900.07 |
| Hazard Information | Back Directory | [Uses]
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2]. | [IC 50]
NK2 | [References]
[1] Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. DOI:10.1046/j.1471-4159.2001.00633.x
[2] Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5. PMID:8627548 |
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