| Identification | Back Directory | [Name]
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[[1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl]amino]methyl]-, hydrochloride (1:1) | [CAS]
1417548-17-4 | [Synonyms]
AM8191
AM-8191
AM 8191
AM-8191 HCl
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[[1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl]amino]methyl]-, hydrochloride (1:1) | [Molecular Formula]
C26H29ClFN5O5 | [MOL File]
1417548-17-4.mol | [Molecular Weight]
546 |
| Hazard Information | Back Directory | [Description]
AM-8191 is a bacterial topoisomerase inhibitors as broad-spectrum antibacterial agent. | [Uses]
AM8191 is an orally active bactericidal and selectively inhibits DNA synthesis and Staphylococcus aureus gyrase (IC50=1.02 μM) and topo IV (IC50=10.4 μM). AM8191 inhibits S. aureus MSSA (MIC=0.02 μg/mL) and S. aureus MRSA (MIC=0.06 μg/mL)[1]. | [References]
[1] Sheo B Singh, et al. Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. ACS Med Chem Lett. 2014 Mar 12;5(5):609-14. DOI:10.1021/ml500069w |
|
|