| Identification | Back Directory | [Name]
1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- | [CAS]
1417638-60-8 | [Synonyms]
3-[4-[[[2,6-Bis[[4-(2-aminoethoxy)-2-quinolyl]carbamoyl]-4-pyridyl]oxy]methyl]-1H-1,2,3-triazol-1-yl]propanoic Acid
1H-1,2,3-Triazole-1-propanoic acid, 4-[[[2,6-bis[[[4-(2-aminoethoxy)-2-quinolinyl]amino]carbonyl]-4-pyridinyl]oxy]methyl]- | [Molecular Formula]
C35H34N10O7 | [MOL File]
1417638-60-8.mol | [Molecular Weight]
706.71 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: 25 mg/mL, clear | [form ]
powder | [color ]
white to light brown | [Water Solubility ]
H2O: 25mg/mL, clear |
| Hazard Information | Back Directory | [Uses]
Carboxypyridostatin trifluoroacetate salt has been used in the study of translation, stimulated by DHX36 (DEAH-box helicase 36) binding at G-rich sites in mRNA untranslated regions. | [Biochem/physiol Actions]
Carboxypyridostatin (carboxyPDS) selectively stabilizes RNA-containg G-quadruplex stuctures. Immunofluorescent staining of carboxyPDS treated cells using an anti G-quadruplex antibody reveals staining only in the cytoplasm and not the nucleus, demonstrating selectivity against DNA G-quadruplex structures. | [in vivo]
Carboxypyridostatin (10 mg/kg; i.p.; every 12 h; 3 injections) significantly reduces the number of PCNA-expressing cells in the adult SVZ and increases the number of OLIG2-expressing cells in the corpus callosum in mice[1].
| Animal Model: | C57BL/6 mice (both sexes, 1-2 months old)[1] | | Dosage: | 10 mg/kg (dissolved in phosphate-buffered saline) | | Administration: | Intraperitoneal injection, every 12 h, 3 injections | | Result: | Reduced the number of PCNA-expressing cells in the adult SVZ of mice, indicating a decrease in cell proliferation.
Increased the number of OLIG2-expressing cells in the corpus callosum.
Showed no increase in OLIG2-expression in the SVZ.
Affected the differentiation of neural stem and progenitor cells in different brain regions.
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| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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