| Identification | Back Directory | [Name]
(R)-N-(1-(benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide | [CAS]
1418293-40-9 | [Synonyms]
NT160
(R)-N-(1-(benzyl(methyl)amino)propan-2-yl)-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide
Benzamide, N-[(1R)-1-methyl-2-[methyl(phenylmethyl)amino]ethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]- | [Molecular Formula]
C21H21F3N4O2 | [MOL File]
1418293-40-9.mol | [Molecular Weight]
418.41 |
| Hazard Information | Back Directory | [Uses]
NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 can be used for the research of central nervous system diseases[1]. | [IC 50]
HDAC4: 0.08 nM (IC50); HDAC5: 1.2 nM (IC50); HDAC7: 1.0 nM (IC50); HDAC9: 0.9 nM (IC50) | [References]
[1] Turkman N, et al. Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy. Eur J Med Chem. 2022;228:114011. DOI:10.1016/j.ejmech.2021.114011 |
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Abosyn
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0512-69561983 13914027025 |
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abosyn.cn/ |
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