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141979-19-3

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141979-19-3 Structure

141979-19-3 Structure
IdentificationBack Directory
[Name]

16-Hydroxycleroda-3,13-dien-15,16-olide
[CAS]

141979-19-3
[Synonyms]

16-Hydroxycleroda-3,13-dien-15,16-olide
2(5H)-Furanone, 5-hydroxy-4-[2-[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]ethyl]-
[Molecular Formula]

C20H30O3
[MOL File]

141979-19-3.mol
[Molecular Weight]

318.45
Chemical PropertiesBack Directory
[Boiling point ]

465.6±40.0 °C(Predicted)
[density ]

1.057±0.06 g/cm3(Predicted)
[pka]

10.01±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

16-Hydroxycleroda-3,13-dien-15,16-olide (16ξ-Hydroxycleroda-3,13-dien-15,16-olide; HCD), a clerodane diterpene, is a potent serine protease dipeptidyl peptidase 4 (DPP-4) inhibitor. 16-Hydroxycleroda-3,13-dien-15,16-olide down-regulates LPS-induced ERK phosphorylation in myocyte but blocks GLP-1 induced PKA expression. 16-Hydroxycleroda-3,13-dien-15,16-olide exhibits hypolipidemic, hepatoprotective, hypoglycemic efficacy[1].
[References]

[1] Po-Kai Huang, et al. Polyalthia Clerodane Diterpene Potentiates Hypoglycemia via Inhibition of Dipeptidyl Peptidase 4. Int J Mol Sci. 2019 Jan 27;20(3):530. DOI:10.3390/ijms20030530
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