| Identification | Back Directory | [Name]
SFTX-3.3 | [CAS]
141997-14-0 | [Synonyms]
SFTX-3.3
Pentanamide, 2-amino-5-[(aminoiminomethyl)amino]-N-[3-[(3-aminopropyl)amino]propyl]-, (2S)- | [Molecular Formula]
C12H29N7O | [MDL Number]
MFCD01324663 | [MOL File]
141997-14-0.mol | [Molecular Weight]
287.4 |
| Hazard Information | Back Directory | [Uses]
sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels[1][2]. | [IC 50]
P/Q-type calcium?channel: 0.24 mM (IC50); N-type calcium channel: 0.70 mM (IC50) | [References]
[1] Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44(3):315-21. DOI:10.1046/j.1528-1157.2003.41102.x
[2] T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50(4):939-46. PMID:8863840
[3] M Fatehi, et al. Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology. 1997 Feb;36(2):185-94. DOI:10.1016/s0028-3908(96)00146-3 |
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