| Identification | Back Directory | [Name]
γ-Secretase modulator 4 | [CAS]
1420200-82-3 | [Synonyms]
γ-Secretase modulator 4
γ-Secretase modulator 4
γSecretase modulator 4,γ Secretase modulator 4
1H-Indole-5-carbonitrile, 2-[(8S)-8-(3-fluoro-2-methylphenyl)-5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl]-4-methoxy- | [Molecular Formula]
C23H19FN4O2 | [MDL Number]
MFCD32067962 | [MOL File]
1420200-82-3.mol | [Molecular Weight]
402.42 |
| Chemical Properties | Back Directory | [Boiling point ]
733.8±60.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
14.39±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.014 μM and 0.017 μM in human and mouse, respectively[1]. | [References]
[1] Bischoff FP, et al. Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1737-1745. DOI:10.1016/j.bmcl.2019.05.023 |
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