| Identification | Back Directory | [Name]
(-)-Donepezil | [CAS]
142057-80-5 | [Synonyms]
S-(-)-DONEPEZIL
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, (2S)- | [Molecular Formula]
C24H29NO3 | [MOL File]
142057-80-5.mol | [Molecular Weight]
379.49 |
| Chemical Properties | Back Directory | [Melting point ]
108-110°C | [Boiling point ]
527.9±50.0 °C(Predicted) | [density ]
1.141±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.84±0.10(Predicted) | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
(-)-Donepezil is an isomer of Donepezil (D531750), a nootropic, acting as an inhibitor of acetylcholinesterase. | [Definition]
ChEBI: Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nootropic agent and an EC 3.1.1.8 (cholinesterase) inhibitor. It contains a (R)-donepezil and a (S)-donepezil. It is a conjugate base of a donepezil (1+). |
|
|