| Identification | Back Directory | [Name]
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate | [CAS]
1420859-80-8 | [Synonyms]
1-Boc-3-(2-bromoethyl)azetidine
tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
3-(2-Bromo-ethyl)-azetidine-1-carboxylic acid tert-butyl ester
1-Azetidinecarboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H18BrNO2 | [MDL Number]
MFCD24382790 | [MOL File]
1420859-80-8.mol | [Molecular Weight]
264.16 |
| Chemical Properties | Back Directory | [Boiling point ]
298.1±13.0 °C(Predicted) | [density ]
1.320±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [pka]
-1.68±0.40(Predicted) | [Appearance]
Colorless to light yellow Liquid | [InChI]
InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-8(7-12)4-5-11/h8H,4-7H2,1-3H3 | [InChIKey]
IMCAWEYWTGJUEH-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC(CCBr)C1 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate from tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate: To a solution of tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (6.1 g, 30.3 mmol) in dichloromethane (100 mL) was added, in sequence, at 0 °C carbon tetrabromide (19.8 g 60.6 mmol) and triphenylphosphine (15.7 g, 60.6 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate (5.5 g, 69.4% yield) as a colorless oil.LC-MS m/z: 208 [M+H-56]. | [References]
[1] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00255 |
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| Company Name: |
TaiChem Taizhou Limited
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| Tel: |
052386810091 |
| Website: |
https://www.chemicalbook.com/supplier/11410902/1.htm |
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