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1421373-62-7

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1421373-62-7 Structure

1421373-62-7 Structure
IdentificationBack Directory
[Name]

Mutant EGFR inhibitor
[CAS]

1421373-62-7
[Synonyms]

MDK3627
ABM-3627
Mutant EGFR inhibitor
N-[5-[[5-Chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-2-propenamide
2-Propenamide, N-[5-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-
[Molecular Formula]

C27H30ClN7O2
[MDL Number]

MFCD28167737
[MOL File]

1421373-62-7.mol
[Molecular Weight]

520.03
Chemical PropertiesBack Directory
[density ]

1.316±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

12.66±0.70(Predicted)
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M.
[IC 50]

EGFRL858R; EGFRExon 19 deletion; EGFRT790M
[References]

[1] WO 2013014448 A1
Spectrum DetailBack Directory
[Spectrum Detail]

Mutant EGFR inhibitor(1421373-62-7)1HNMR
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