| Identification | Back Directory | [Name]
(6S,9S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl- 4,7-dioxo-8-(quinolin-8-ylmethyl)hexahydro-2H- pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide | [CAS]
1422253-37-9 | [Synonyms]
(6S,9S,9AS)-N-BENZYL-6-(4-HYDROXYBENZYL)-2,9-DIMETHYL- 4,7-DIOXO-8-(QUINOLIN-8-YLMETHYL)HEXAHYDRO-2H
(6S,9S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl- 4,7-dioxo-8-(quinolin-8-ylmethyl)hexahydro-2H- pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, hexahydro-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-N-(phenylmethyl)-8-(8-quinolinylmethyl)-, (6S,9S,9aS)- | [Molecular Formula]
C33H34N6O4 | [MDL Number]
MFCD32664545 | [MOL File]
1422253-37-9.mol | [Molecular Weight]
578.66 |
| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml
Methanol: Sparingly soluble: 1-10 mg/ml | [pka]
9.88±0.15(Predicted) | [InChIKey]
KLGHKOORFHZFGO-AZXNYEMZSA-N | [SMILES]
N1(C)CC(=O)N2[C@@H](CC3=CC=C(O)C=C3)C(=O)N(CC3=C4C(=CC=C3)C=CC=N4)[C@@H](C)[C@]2([H])N1C(NCC1=CC=CC=C1)=O |
| Hazard Information | Back Directory | [Uses]
C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300[1]. | [in vivo]
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile[1]. | [References]
[1] Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP)-response Element-binding Protein (CREB)-binding Protein (CBP)/β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2(11):1751-8. DOI:10.1016/j.ebiom.2015.10.010 |
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