| Identification | Back Directory | [Name]
(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL | [CAS]
142227-49-4 | [Synonyms]
(R)-BM 14686
(S)-BM 14686
(S)-BM 140686
(R)-BM 140686
(R)-4-Hydroxycarvedilol
(S)-4-Hydroxycarvedilol
Carvedilol 4-Hydroxy Metabolite
(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL
(S)-(-)-4'-HYDROXYPHENYL-CARVEDILOL
Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]aMino]ethoxy]-3-Methoxyphenol
(R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
(S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol | [Molecular Formula]
C24H26N2O5 | [MDL Number]
MFCD04116168 | [MOL File]
142227-49-4.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Appearance]
Off-White Solid | [Melting point ]
163-165°C | [Boiling point ]
702.0±60.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
9.94±0.20(Predicted) | [color ]
White to Light Brown |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension. | [Uses]
An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity. | [Uses]
An optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension | [Description]
4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay. | [Definition]
ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles. | [storage]
Store at -20°C | [References]
[1] DAXESH P. PATEL. UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers[J]. Biomedical Chromatography, 2013, 27 8: 974-986. DOI: 10.1002/bmc.2889
[2] H G OLDHAM S E C. In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.[J]. Drug Metabolism and Disposition, 1997, 25 8: 970-977.
[3] THOMAS C MALIG. Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolites.[J]. MedChemComm, 2017: 606-615. DOI: 10.1039/c7md00014f |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|