| Identification | Back Directory | [Name]
N-METHYL MESOPORPHYRIN IX | [CAS]
142234-85-3 | [Synonyms]
N-METHYL MESOPORPHYRIN IX
8,13-Diethyl-3,7,12,17,23-pentamethyl-21H,23H-porphine-2,18-dipropanoic acid
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl-
21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethyl-3,7,12,17,23-pentamethyl- (9ci) | [Molecular Formula]
C35H40N4O4 | [MDL Number]
MFCD00216786 | [MOL File]
142234-85-3.mol | [Molecular Weight]
580.72 |
| Chemical Properties | Back Directory | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.17 mg/ml; DMSO: 15 mg/ml | [form ]
A crystalline solid | [color ]
Brown to black |
| Hazard Information | Back Directory | [Uses]
N-Methylmesoporphyrin IX (NMM), a widely used G-quadruplex DNA specific fluorescent binder, is an efficient probe for monitoring Aβ fibrillation. N-Methylmesoporphyrin IX is an in situ inhibitor and an ex situ monitor for Aβ amyloidogenesis both in vitro and in cells. N-Methylmesoporphyrin IX is sensitive to G-quadruplexes DNA but has no response to duplexes, triplexes and single-stranded forms DNA. N-Methylmesoporphyrin IX is nonfluorescent alone or in monomeric Aβ environments, but emits strong fluorescence through stacking with the Aβ assemblies[1]. | [References]
[1] Meng Li, et al. N-Methyl Mesoporphyrin IX as an Effective Probe for Monitoring Alzheimer's Disease β-Amyloid Aggregation in Living Cells. ACS Chem Neurosci. 2017 Jun 21;8(6):1299-1304. DOI:10.1021/acschemneuro.6b00436 |
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