| Identification | Back Directory | [Name]
1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid | [CAS]
1422386-02-4 | [Synonyms]
1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid
1-Piperidinecarboxylic acid, 3-(4-carboxy-1H-pyrazol-1-yl)-, 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C14H21N3O4 | [MDL Number]
MFCD25371800 | [MOL File]
1422386-02-4.mol | [Molecular Weight]
295.33 |
| Chemical Properties | Back Directory | [Boiling point ]
470.7±35.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
powder | [pka]
3.83±0.10(Predicted) | [InChI]
1S/C14H21N3O4/c1-14(2,3)21-13(20)16-6-4-5-11(9-16)17-8-10(7-15-17)12(18)19/h7-8,11H,4-6,9H2,1-3H3,(H,18,19) | [InChIKey]
ZTQAPANOXVJNDD-UHFFFAOYSA-N | [SMILES]
CC(C)(OC(N1CCCC(N2C=C(C(O)=O)C=N2)C1)=O)C |
| Hazard Information | Back Directory | [Uses]
1-(1-(tert-Butoxycarbonyl)piperidin-3-yl)-1H-pyrazole-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
920533
920649
920665
920703 | [reaction suitability]
reagent type: linker |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|