| Identification | Back Directory | [Name]
2,5,6-trichloronicotinaMide | [CAS]
142266-62-4 | [Synonyms]
2,5,6-trichloronicotinaMide
2,5,6-Trichloro-3-pyridinecarboxaMide
2,5,6-trichloropyridine-3-carboxamide
3-Pyridinecarboxamide, 2,5,6-trichloro- | [Molecular Formula]
C6H3Cl3N2O | [MDL Number]
MFCD22493418 | [MOL File]
142266-62-4.mol | [Molecular Weight]
225.46 |
| Chemical Properties | Back Directory | [Boiling point ]
290.0±40.0 °C(Predicted) | [density ]
1.643±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
13.32±0.50(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2,5,6-trichloropyridin-3-amide from 2,5,6-trichloronicotinoyl chloride: a solution of dioxane (20 ml) of 2,5,6-trichloronicotinoyl chloride (2.5 g, 10.2 mmol) was slowly added dropwise to 10 ml of ammonium hydroxide (28% NH3 aqueous solution) at 0 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 0°C for 10 min. Subsequently, extraction was carried out with dichloromethane (3 x 50 ml). All organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 2,5,6-trichloropyridin-3-amide (2.3 g, 100% yield), which could be used in subsequent reactions without further purification. | [References]
[1] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 109
[2] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 6, p. 1793 - 1804
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 10, p. 2958 - 2961 |
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