| Chemical Properties | Back Directory | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [pka]
3.25±0.10(Predicted) | [Water Solubility ]
Soluble to 1 mg/ml in sterile water |
| Hazard Information | Back Directory | [Uses]
Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2]. | [in vivo]
Pep2m, myristoylated (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2].
| Animal Model: | Female and male Long-Evans hooded rats (8 weeks)[2] | | Dosage: | 10 μg (in 20 μL) | | Administration: | Intrathecal injection | | Result: | Resulted in an increase in PWTs, in both male and female rats at various time points tested. |
| [References]
[1] Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827. DOI:10.1523/JNEUROSCI.0223-08.2008
[2] Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582. DOI:10.1177/1744806919840582 |
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