| Identification | Back Directory | [Name]
4-Pyrimidinamine, 2-methyl-6-[[(1S,2S)-2-(5-methyl-2-pyridinyl)cyclopropyl]methoxy]-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]- | [CAS]
1424371-93-6 | [Synonyms]
MK-8189
SWMS-172-510
2-methyl-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-6-{[(1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl]methoxy}pyrimidin-4-amine
4-Pyrimidinamine, 2-methyl-6-[[(1S,2S)-2-(5-methyl-2-pyridinyl)cyclopropyl]methoxy]-N-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]- | [Molecular Formula]
C19H22N6OS | [MOL File]
1424371-93-6.mol | [Molecular Weight]
382.48 |
| Chemical Properties | Back Directory | [Boiling point ]
631.1±55.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.08±0.29(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1]. | [in vivo]
MK-8189 (0.25-0.75 mg/kg; po) attenuates rats' locomotor activity in a dose-dependent manner[1]. | Animal Model: | Male Wistar-Hannover rats[1] | | Dosage: | 0.25, 0.5, and 0.75 mg/kg | | Administration: | Oral administration | | Result: | Improved identification ability relative to the vector handling animal. |
| [IC 50]
PDE10A: 29 pM (Ki) | [References]
[1] Layton ME, et, al. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia. J Med Chem. 2023 Jan 26;66(2):1157-1171. DOI:10.1021/acs.jmedchem.2c01521 |
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| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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| Tel: |
020-13556033878 2965585218 13556033878 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
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