| Identification | Back Directory | [Name]
5-HT1A modulator 1 | [CAS]
142477-34-7 | [Synonyms]
5-HT1A modulator 1
2(3H)-Benzothiazolone, 6-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl- | [Molecular Formula]
C21H25N3O2S | [MDL Number]
MFCD30533340 | [MOL File]
142477-34-7.mol | [Molecular Weight]
383.51 |
| Hazard Information | Back Directory | [Uses]
6-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-3-methyl-2(3H)-benzothiazolone, has shown very high affinities for the 5HT1A, adrenergic α1 and dopamine D2 receptor with IC50s of 2 ±0.3 nM, 10 ± 3 nM and 40 ±9 nM, respectively. | [in vivo]
5-HT1A modulator 1 (Compound 24) shows clear antagonist action at 5HT2A receptor subtype in mice. The antagonism is nearly complete at the dose of 1 mg/kg ip for 5-HT1A modulator 1 (94% of antagonism, p<0.01). 5-HT1A modulator 1 completely blocks the stereotypies and the climbing at the dose of 1 mg/kg ip (100% of antagonism). 5-HT1A modulator 1 is also tested in rats, using the same paradigm. After oral administration, 5-HT1A modulator 1 significantly (p<0.05) reduces the hyperactivity by 50% at the doses of 2 and 4 mg/kg po, respectively 63% and 58% of antagonism for 5-HT1A modulator 1; the antagonism is complete (103% and 108%) at the respective doses of 8 and 16 mg/kg po for 5-HT1A modulator 1 (p<0.01)[1]. | [IC 50]
sPLA2: 2 nM (IC50); 5-HT2A Receptor: 500 nM (IC50); 5-HT2C Receptor: 4000 nM (IC50); α1 receptor: 10 nM (IC50); D2 receptor: 40 nM (IC50) | [storage]
Store at -20°C |
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