| Identification | Back Directory | [Name]
1-[2-(4-octylphenyl)ethyl]piperidin-4-ol | [CAS]
1425049-20-2 | [Synonyms]
1-[2-(4-octylphenyl)ethyl]piperidin-4-ol | [Molecular Formula]
C21H35NO | [MDL Number]
MFCD28160780 | [MOL File]
1425049-20-2.mol | [Molecular Weight]
317.509 |
| Hazard Information | Back Directory | [Description]
RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradation of SK1 in human pulmonary arterial smooth muscle cells. | [Uses]
RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 μM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer[1]. | [IC 50]
SphK1: 3.6 μM (IC50) | [References]
[1] Baek D J, et al. Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors[J]. Journal of medicinal chemistry, 2013, 56(22): 9310-9327. DOI:10.1021/jm401399c |
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