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1425485-87-5

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1425485-87-5 Structure

1425485-87-5 Structure
IdentificationBack Directory
[Name]

1-Propanesulfonamide, N-[2,4,5-trifluoro-3-[[3-(4-morpholinyl)-6-quinoxalinyl]carbonyl]phenyl]-
[CAS]

1425485-87-5
[Synonyms]

RX208
B-Raf IN 10
RX208 B-Raf IN 10
1-Propanesulfonamide, N-[2,4,5-trifluoro-3-[[3-(4-morpholinyl)-6-quinoxalinyl]carbonyl]phenyl]-
[Molecular Formula]

C22H21F3N4O4S
[MOL File]

1425485-87-5.mol
[Molecular Weight]

494.49
Chemical PropertiesBack Directory
[Boiling point ]

688.2±65.0 °C(Predicted)
[density ]

1.464±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

5.03±0.10(Predicted)
[color ]

Light yellow to yellow
Hazard InformationBack Directory
[Uses]

Uplarafenib (B-Raf IN 10) (Compound C09) is a BRAF inhibitor with an IC50 between 50 and 100 nM. Uplarafenib shows antitumor activity[1].
[IC 50]

BRAF-V600E: < 50 nM (IC50); Braf: 50-100 nM (IC50)
[References]

[1] Yong-Liang Zhu, et al. Certain Chemical Entities, Compositions, and Methods. Patent US20130053384 A1.
Spectrum DetailBack Directory
[Spectrum Detail]

1-Propanesulfonamide, N-[2,4,5-trifluoro-3-[[3-(4-morpholinyl)-6-quinoxalinyl]carbonyl]phenyl]-(1425485-87-5)1HNMR
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