| Identification | Back Directory | [Name]
Macrocarpal C | [CAS]
142628-53-3 | [Synonyms]
Macrocarpal C
Macrocarpal C/G
1,3-Benzenedicarboxaldehyde,5-[(1R)-1-[(1aR,4aR,7S,7aR,7bR)-decahydro-1,1,7-trimethyl-4-methylene-1H-cycloprop[e]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxy-
5-[(1R)-1-[(1aR,4aR,7S,7aR,7bR)-1,1,7-trimethyl-4-methylidene-1a,2,3,4a,5,6,7a,7b-octahydrocyclopropa[h]azulen-7-yl]-3-methylbutyl]-2,4,6-trihydroxybenzene-1,3-dicarbaldehyde | [Molecular Formula]
C28H38O5 | [MDL Number]
MFCD17214864 | [MOL File]
142628-53-3.mol | [Molecular Weight]
454.6 |
| Chemical Properties | Back Directory | [Boiling point ]
509.6±50.0 °C(Predicted) | [density ]
1.20±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
5.40±0.50(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Description]
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purification, the antifungal action of macrocarpal C was associated with increases of membrane permeability, intracellular ROS and DNA fragmentation. | [Uses]
Macrocarpal C can be isolated from the 95 % ethanol extract of fresh leaves of E. globulus. Macrocarpal C inhibits the growth of T. mentagrophytes via an increase in the permeability of the fungal membrane. Macrocarpal C increases the production of intracellular ROS and? induces apoptosis as a consequence of DNA fragmentation[1]. | [Definition]
ChEBI: Macrocarpal C is a sesquiterpenoid. | [target]
ROS | Antifection | [References]
[1] Jack Ho Wong, et al. Antifungal mode of action of macrocarpal C extracted from Eucalyptus globulus Labill (Lan An) towards the dermatophyte Trichophyton mentagrophytes. Chin Med. 2015, 10, 34. |
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