| Identification | Back Directory | [Name]
HBX 28258 | [CAS]
1426544-54-8 | [Synonyms]
HBX 28258
2-Acridinecarboxamide, 9-chloro-N-[3-[ethyl(phenylmethyl)amino]propyl]-5,6,7,8-tetrahydro- | [Molecular Formula]
C26H30ClN3O | [MOL File]
1426544-54-8.mol | [Molecular Weight]
435.99 |
| Hazard Information | Back Directory | [Description]
HBX28258 is an inhibitor of recombinant human USP7 protein. It acts by binding the active site through covalent mechanism and selectively inactivating USP7 protein in human colon cancer and embryonic kidney cell. | [Uses]
HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53[1]. | [IC 50]
USP7: 22.6 μM (IC50) | [References]
[1] Qi SM, et, al. Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet? Front Cell Dev Biol. 2020 Apr 2:8:233. DOI:10.3389/fcell.2020.00233 |
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