142715-48-8

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142715-48-8 Structure

Identification	Back Directory
[Name] 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
[CAS] 142715-48-8
[Synonyms] CP-100356 Monohydrochloride 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride
[Molecular Formula] C31H37ClN4O6
[MDL Number] MFCD00911858
[MOL File] 142715-48-8.mol
[Molecular Weight] 597.102

Chemical Properties	Back Directory
[storage temp. ] 2-8°C
[solubility ] DMSO: >5mg/mL
[form ] powder
[color ] white to off-white
[InChIKey] WWCHXVYTCMPAMV-UHFFFAOYSA-N
[SMILES] Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC

Safety Data	Back Directory
[WGK Germany ] 3
[Storage Class] 11 - Combustible Solids

Hazard Information	Back Directory
[Chemical Properties] Off-White to Light Tan Solid
[Uses] CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
[in vivo] CP-100356 (6-24 mg/kg; p.o.) increases the systemic exposure of Fexofenadine (36- and 80-fold increase in C_max and AUC at the dose of 24 mg/kg) in rats^[1].
[storage] Desiccate at RT

Spectrum Detail	Back Directory
[Spectrum Detail] 4-(3,4-Dihydro-6,7-diMethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-diMethoxyphenyl)ethyl]-6,7-diMethoxy-2-quinazolinaMine Monohydrochloride(142715-48-8)¹HNMR

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