| Identification | Back Directory | [Name]
(5-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone | [CAS]
1427325-65-2 | [Synonyms]
(5-methoxynaphthalen-1-yl)-(1-pentylindol-3-yl)methanone
(5-methoxynaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone | [Molecular Formula]
C25H25NO2 | [MOL File]
1427325-65-2.mol | [Molecular Weight]
371.47 |
| Hazard Information | Back Directory | [Description]
JWH 081 is a synthetic cannabinoid (CB) that shows a high-affinity for the central CB1 receptor with a Ki value of 1.2 nM and ten-fold reduced affinity for the peripheral CB2 receptor (Ki = 12.4 nM).1,2 JWH 081 5-methoxynaphthyl isomer differs structurally from JWH 081 by having the methoxy group attached to the naphthyl rings at the 5 position, instead of the 4 position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes. | [References]
1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Huffman, J.W., Zengin, G., Wu, M.J., et al. Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: Steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists Bioorg. Med. Chem. 13(1),89-112(2005). |
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