| Identification | Back Directory | [Name]
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT | [CAS]
142754-28-7 | [Synonyms]
Sp-8-Cl-cAMPS
SP-8-CL-CAMPS, NA
SP-8-CL-CAMPS SODIUM SALT
8-chloroadenosine-3’,5’-cyclicmonophosphorothioate
ADENOSINE, 8-CHLORO-,CYCLIC 3',5'-[HYDROGEN (S)-P...
8-Chloroadenosine-3'',5''-cyclic monophosphothioate sodium salt Sp isomer
8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER SODIUM SALT
8-chloroadenosine-3’,5’-cyclicmonophosphorothioate,sp-isomer(sp-8-cl-camps)
ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-CHLORO-, SP-ISOMER, SODIUM SALT | [Molecular Formula]
C10H10ClN5NaO5PS | [MDL Number]
MFCD03452651 | [MOL File]
142754-28-7.mol | [Molecular Weight]
401.7 |
| Hazard Information | Back Directory | [Uses]
Sp-8-Cl-cAMPS is an analog of cAMP (HY-B1511) and a derivative of Sp-8-Cl-cAMP. Sp-8-Cl-cAMPS inhibits the growth of human leukemia cell HL-60 and colon cancer cell LS-174T, with IC50 of 8-100 μM. Sp-8-Cl-cAMPS activates the protein kinases cAKI and cAKII, with Ka of 0.25 and 3.2 μM[1]. | [References]
[1] Yokozaki H, et al., Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52(9):2504-8. PMID:1314695 |
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