| Identification | Back Directory | [Name]
Domperidone Impurity 15 | [CAS]
142799-22-2 | [Synonyms]
Domperidone Impurity 15
1,3-Bis(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one
2H-Benzimidazol-2-one, 1,3-bis(3-chloropropyl)-1,3-dihydro-
1,3-Bis(3-Chloropropyl)-1,3-dihydro-2H-benzo[d]imidazol-2-one | [Molecular Formula]
C13H16Cl2N2O | [MOL File]
142799-22-2.mol | [Molecular Weight]
287.18 |
| Chemical Properties | Back Directory | [Melting point ]
66°C | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Water (Slightly, Heated, Sonicated) | [form ]
Solid | [color ]
White to Off-White |
| Hazard Information | Back Directory | [Uses]
1,3-Bis(3-chloropropyl)-1,3-dihydro-2H-benzimidazol-2-one (~90%) is an intermediate in the synthesis of 3’-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]propyl Domperidine (Domperidine Impurity F) (C365315), an impurity of the gastrokinetic and antinauseant drug Domperidone (D531100(P)), which is a novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. |
|
|