| Identification | Back Directory | [Name]
MRT-92 | [CAS]
1428315-82-5 | [Synonyms]
MRT-92
Benzamide, N-[imino[[4-methyl-3-[[4-(2-phenylethyl)benzoyl]amino]phenyl]amino]methyl]-3,4,5-trimethoxy- | [Molecular Formula]
C33H34N4O5 | [MOL File]
1428315-82-5.mol | [Molecular Weight]
566.65 |
| Hazard Information | Back Directory | [Uses]
MRT-92 is a Smoothened (Smo) antagonist (Ki=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC50=0.4 nM). MRT-92 can be used in the study of cerebellar glioma[1]. | [References]
[1] Hoch, et al. "MRT-92 inhibits Hedgehog signaling by blocking overlap** binding sites in the transmembrane domain of the Smoothened receptor." The FASEB Journal 29.5 (2015): 1817. DOI:10.1096/fj.14-267849 |
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